Structural and Antimicrobial Characterization of Co-Crystal [Ni(bpy)(acr)2(H2O)]·MA

A new co-crystal with the formula [Ni(bpy)(acr)2(H2O)]·MA (bpy = 2,2′-bipyridine, acr acrylate and MA melamine) has been synthesized characterized using IR, UV-Vis, thermogravimetric analysis single crystal X-ray diffraction. The complex contains discrete unities of [Ni(bpy)(acr)2(H2O)] melamine linked in a network by both hydrogen bonds π-π stacking interactions. Structural characterization revealed that Ni(II) adopts an octahedral distorted stereochemistry, ions present unidentate chelate coordination modes. Thermal decomposition occurs four steps, ligands being stepwise released order water, acrylate, bipyridine melamine. antimicrobial activity obtained complex, its precursor ([Ni(bpy)(acr)2(H2O)]) were assessed against planktonic (minimal inhibitory concentration—MIC) biofilm-embedded biofilm eradication concentration—MBEC) Gram-positive Gram-negative bacterial strains. results exhibited superior compared to MA, highest susceptibility recorded for Staphylococcus aureus strain. MIC MBEC ranges very similar, indicating potential this develop novel anti-biofilm agents.